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- Title
Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variant.
- Authors
Ge, Peicong; Zhang, Qian; Ye, Xun; Liu, Xingju; Deng, Xiaofeng; Wang, Jia; Wang, Rong; Zhang, Yan; Zhang, Dong; Zhao, Jizong
- Abstract
<bold>Background: </bold>The aim of this study was to investigate the hemorrhgic sites and collateral vessels in hemorrhagic MMD with the p.R4810K variant.<bold>Methods: </bold>Hemorrhage sites were classified as either anterior or posterior. Collateral vessels were classified into three subtypes according to origin: lenticulostriate anastomosis, thalamic anastomosis, and choroidal anastomosis. Hemorrhage sites and collateral vessels were compared between patients with wild-type p.R4810K variant (GG) and patients with heterozygous p.R4810K variant (GA) after 1:1 propensity score matching.<bold>Results: </bold>A total of 130 hemorrhagic MMD patients were included in present study, 21 pairs (42 hemorrhagic hemispheres) were obtained after 1:1 propensity score. In GA group, 16 hemispheres (76.2%) presented anterior hemorrhage, and 5 hemispheres (23.8%) presented with posterior hemorrhage. In GG group, 13 hemispheres (61.9%) presented anterior hemorrhage, and 8 hemispheres (38.1%) presented with posterior hemorrhage. No significant differences were found in hemorrhagic sites between two matched groups (P > 0.05). Of 21 hemispheres in GA group, 10 (47.6%) exhibited lenticulostriate anastomosis, 6 (28.6%) thalamic anastomosis, and 6 (28.6%) choroidal anastomosis. Of 21 hemispheres in GG group, 3 (14.3%) exhibited lenticulostriate anastomosis, 5 (23.8%) thalamic anastomosis, and 9 (42.9%) choroidal anastomosis. There was significant difference in lenticulostriate anastomosis between two matched groups (P = 0.045). After adjustment the age, sex, and PCA involvement, we found that lenticulostriate anastomosis was associated with p.R4810K variant (OR, 5.995; 95% CI, 1.296-27.737; P = 0.022).<bold>Conclusion: </bold>Lenticulostriate anastomosis might be associated with p.R4810K variant. Whereas hemorrhagic sites, thalamic anastomosis, and choroidal anastomosis might not be associted withp.R4810K variant.
- Subjects
MOYAMOYA disease; HEMORRHAGIC diseases; PROPENSITY score matching; ADENOSINE triphosphatase; BASAL ganglia diseases; CEREBRAL angiography; CEREBRAL hemorrhage; CEREBROVASCULAR disease; COLLATERAL circulation; ENZYMES; GENETICS; GENETIC carriers; DISEASE complications
- Publication
BMC Neurology, 2020, Vol 20, Issue 1, pN.PAG
- ISSN
1471-2377
- Publication type
journal article
- DOI
10.1186/s12883-020-01884-0