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- Title
Midbrain/pons area ratio and clinical features predict the prognosis of progressive Supranuclear palsy.
- Authors
Cui, Shi-Shuang; Ling, Hua-Wei; Du, Juan-Juan; Lin, Yi-Qi; Pan, Jing; Zhou, Hai-Yan; Wang, Gang; Wang, Ying; Xiao, Qin; Liu, Jun; Tan, Yu-Yan; Chen, Sheng-Di
- Abstract
<bold>Background: </bold>Progressive supranuclear palsy (PSP) is a rare movement disorder with poor prognosis. This retrospective study aimed to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of daily living.<bold>Method: </bold>All patients recruited fulfilled the movement disorder society (MDS) clinical diagnostic criteria for PSP (MDS-PSP criteria) for probable and possible PSP with median 12 years. Data were obtained including age, sex, date of onset, age at onset (AAO), symptoms reported at first visit and follow-up, date of death and date of institutionalization. Magnetic resonance imaging was collected at the first visit. Endpoints were death and institutionalization. Kaplan-Meier method and Cox proportional hazard model were used to explore factors associated with early death and institutionalization.<bold>Results: </bold>Fifty-nine patients fulfilling MDS-PSP criteria were enrolled in our study. Nineteen patients (32.2%) had died and 31 patients (52.5%) were institutionalized by the end of the follow-up. Predictors associated with poorer survival were late-onset PSP and decreased M/P area ratio. Predictors associated with earlier institutionalization were older AAO and decreased M/P area ratio.<bold>Conclusion: </bold>Older AAO and decreased M/P area ratio were predictors for earlier dearth and institutionalization in PSP. The neuroimaging biomarker M/P area ratio was a predictor for prognosis in PSP.
- Subjects
PROGRESSIVE supranuclear palsy; PROPORTIONAL hazards models; MESENCEPHALON; MAGNETIC resonance imaging; PROGNOSIS; MOVEMENT disorders
- Publication
BMC Neurology, 2020, Vol 20, Issue 1, p1
- ISSN
1471-2377
- Publication type
journal article
- DOI
10.1186/s12883-020-01692-6