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- Title
Polycyclic N-Heterocyclic Compounds 83: Synthesis of 2,4-Disubstituted 5,6-Dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5- d]pyrimidines and 2,4,5-Trisubstituted 5,6-Dihydro[1]benzofuro[2′,3′:5,6]pyrano[4,3- d]pyrimidines from 4-Chloro-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5- d]pyrimidines
- Authors
Okuda, Kensuke; Takano, Jun ‐ ichi; Hirota, Takashi; Sasaki, Kenji
- Abstract
Treatment of 2-substituted 4-chloro-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5- d]pyrimidines with simple alcohols and thiols as nucleophile afforded 2-substituted 4-alkoxy (or sulfanyl) derivatives. In the case of alkoxide nucleophiles, rearranged reaction products were also obtained. X-ray crystallography was used to support the structure assignment of the rearranged product.
- Subjects
HETEROCYCLIC compounds synthesis; PYRIMIDINES; PYRANONES; THIOLS; NUCLEOPHILES; ALKOXY compound derivatives; X-ray crystallography
- Publication
Journal of Heterocyclic Chemistry, 2014, Vol 51, Issue 3, p788
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1900