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- Title
Nonaqueous Capillary Electrophoretic Enantioseparation of Water Insoluble Tröger's Base Derivatives Using β-Cyclodextrin as Chiral Selector.
- Authors
Řezanka, Pavel; Sýkora, David; Novotný, Michal; Havlík, Martin; Král, Vladimír
- Abstract
ABSTRACT Racemic mixtures of six Tröger's base derivatives were separated by chiral nonaqueous . The separation protocol was optimized first for suitable solvents. Then the applicability of various salts dissolved in organic solvents and their mixtures was evaluated. As chiral selectors β-cyclodextrin and heptakis(2,6-di- O-methyl)-β-cyclodextrin at various concentrations were used. The best for the studied analytes was obtained utilizing formamide as organic nonaqueous solvent containing a mixture of sodium citrate and tris(hydroxymethyl)aminomethane acetate as electrolytes, and β-cyclodextrin as chiral additive. The experimental results demonstrated the feasibility of nonaqueous for enantioseparation of Tröger's base derivatives. This technique represents a suitable alternative to more commonly used in aqueous environment. Chirality 25:810-813, 2013. © 2013 Wiley Periodicals, Inc.
- Subjects
CAPILLARY electrophoresis; SEPARATION of enantiomers; TROGER'S base; CHEMICAL derivatives; CYCLODEXTRINS; CHIRAL centers
- Publication
Chirality, 2013, Vol 25, Issue 11, p810
- ISSN
0899-0042
- Publication type
Article
- DOI
10.1002/chir.22220