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- Title
The effect of curcumin in the ectonucleotidases and acetylcholinesterase activities in synaptosomes from the cerebral cortex of cigarette smoke-exposed rats.
- Authors
Jaques, Jeandre Augusto dos Santos; Rezer, João Felipe Peres; Gonçalves, Jamile Fabbrin; Spanevello, Rosélia Maria; Gutierres, Jessié Martins; Pimentel, Victor Câmera; Thomé, Gustavo Roberto; Morsch, Vera Maria; Schetinger, Maria Rosa Chitolina; Leal, Daniela Bitencourt Rosa
- Abstract
With the evidence that curcumin may be a potent neuroprotective agent and that cigarette smoke is associated with a decline in the cognitive performance as our bases, we investigated the activities of Ecto-Nucleoside Triphosphate Diphosphohydrolase (NTPDase), 5'-nucleotidase and acetylcholinesterase (AChE) in cerebral cortex synaptosomes from cigarette smoke-exposed rats treated with curcumin (Cur). The experimental procedures entailed two sets of experiments. In the first set, the groups were vehicle, Cur 12·5, 25 and 50 mg·kg-1; those in the second set were vehicle, smoke, smoke and Cur 12·5, 25 and 50 mg·kg-1. Curcumin prevented the increased NTPDase, 5'-nucleotidase and AChE activities caused by smoke exposure. We suggest that treatment with Cur was protective because the decrease of ATP and acetylcholine (ACh) concentrations is responsible for cognitive impairment, and both ATP and ACh have key roles in neurotransmission. Copyright © 2011 John Wiley & Sons, Ltd.
- Publication
Cell Biochemistry & Function, 2011, Vol 29, Issue 8, p703
- ISSN
0263-6484
- Publication type
Article
- DOI
10.1002/cbf.1804