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- Title
Hydriodic AcidMediated Cyclization of αSubstituted Secondary 2Ethenylbenzamides: Synthesis of 2Substituted 2,3Dihydro3,3dimethyl1Hisoindol1ones and 3,3Disubstituted E1Arylimino1,3dihydroisobenzofurans.
- Authors
Kazuhiro Kobayashi; Seiki Fujita; Daisuke Nakai; Shogo Fukumoto; Shuhei Fukamachi; Hisatoshi Konishi
- Abstract
A new and facile method for the preparation of 2substituted 2,3dihydro3,3dimethyl1Hisoindol1ones 3and 3,3disubstituted E1arylimino1,3dihydroisobenzofurans 6has been developed. Thus, treatment of Nalkylor aryl21methylethen1ylbenzamides 2with concentrated hydriodic acid HI in MeCN at room temperature afforded 3. Similar treatment of Naryl21phenylethen1ylbenzamide 5with concentrated HI at 0° afforded 6.
- Subjects
HYDRIODIC acid; RING formation (Chemistry); BENZAMIDE; ORGANIC synthesis; FURANS; INDOLE; ETHYLBENZENE
- Publication
Helvetica Chimica Acta, 2010, Vol 93, Issue 7, p1274
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201000172