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- Title
Synthesis and Monoamine Oxidase Inhibitory Activity of 3-Substituted 5 H-Indeno[1,2- c]pyridazines.
- Authors
Kneubühler, Silvia; Testa, Bernard; Carta, Vincenzo; Altomare, Cosimo; Carotti, Angelo
- Abstract
The one-pot synthesis of nine 5 H-indeno[1,2- c]pyridazines is described. These compounds are shown to be potent, reversible inhibitors of monoamine oxidase B (MAO-B) with little or no effect on monoamine oxidase A (MAO-A). Qualitative structure-activity relations indicate that the MAO-B inhibitory activity is strongly influenced by electronic and bulk properties of substitutents.
- Publication
Helvetica Chimica Acta, 1993, Vol 76, Issue 5, p1956
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19930760514