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- Title
Influence of anemia on tumor response to preoperative chemoradiotherapy for locally advanced rectal cancer.
- Authors
Seong Dae Lee; Ji Won Park; Kui Seon Park; Seok-Byung Lim; Hee Jin Chang; Dae Yong Kim; Seung-Yong Jeong; Hyo Seong Choi; Jae Hwan Oh
- Abstract
In rectal cancer patients treated with preoperative chemoradiotherapy (CRT) and curative resection, we evaluated the influence of anemia on tumor response to preoperative CRT. Between August 2001 and July 2007, 490 patients underwent preoperative CRT, followed by curative-intent surgery. Tumor responses were evaluated based on tumor regression grade (TRG), T- and N-level downstaging, and volume reduction rates. The level of pretreatment hemoglobin (Hb) was 12.9 ± 1.7 g/dl (range, 7.2–17.6 g/dl). Tumor response rates were significantly different below and above the Hb level of 9.0 g/dl. Specifically, patients with Hb levels ≥9.0 g/dl achieved better tumor responses than those with Hb levels < 9.0 g/dl (rates of TRG 3 or 4—29.0% vs. 0%, p < 0.001). In addition, there is no differences in tumor response between the nontransfusion and transfusion groups of patients with Hb levels ≥9.0 g/dl (rates of TRG 3 or 4—29.1% vs. 23.1%, p = 0.445). The serum Hb level could be a one of prognostic factors that influences the pathologic tumor response, and pretreatment anemia (below 9.0 g/dl of Hb) is associated with poor response to preoperative CRT.
- Subjects
ANEMIA; BLOOD diseases; RECTAL cancer; CANCER chemotherapy; CANCER radiotherapy; HEMOGLOBINS; BLOOD proteins
- Publication
International Journal of Colorectal Disease, 2009, Vol 24, Issue 12, p1451
- ISSN
0179-1958
- Publication type
Article
- DOI
10.1007/s00384-009-0762-7