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- Title
Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular analysis of EORTC 22042–26042.
- Authors
Maas, Sybren L. N.; Sievers, Philipp; Weber, Damien C.; Weller, Michael; van den Bent, Martin J.; Mair, Maximilian J.; Kros, Johan M.; Carparrotti, Fransesca; von Deimling, Andreas; Salvador, Villà Freixa; Peerdeman, Saskia Marguerite; Casas-Martin, Jose; Gorlia, Thierry; Sahm, Felix; Preusser, Matthias
- Abstract
Due to the relatively small cohort and events, the association of I CDKN2A/B i loss and I TERT- i promotor mutations with outcome could not be validated and should be investigated in a larger prospective cohort with longer follow-up. Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular analysis of EORTC 22042-26042 Of the 78 patients enrolled in the trial, 53 patients consented their resected material to be available for further research. Specifically, mutations in the promotor area of the telomerase reverse transcriptase ( I TERT i ) gene and/or homozygous loss of the I CDKN2A/B i locus automatically result in a grade 3 diagnosis [[3]].
- Subjects
DNA methylation; MENINGIOMA; CHROMOSOMES; CENTRAL nervous system tumors; NUCLEOTIDE sequencing
- Publication
Acta Neuropathologica, 2023, Vol 146, Issue 6, p837
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-023-02642-5