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- Title
Ependymoma with neuropil-like islands: a case report with diagnostic and histogenetic implications.
- Authors
Gessi, Marco; Marani, Carla; Geddes, Jennian; Arcella, Antonella; Cenacchi, Giovanna; Giangaspero, Felice
- Abstract
We describe a case of ependymoma with neuronal differentiation in form of neuropil-like islands. A 6-year-old boy presented at clinical examination for a short history of headaches and vomiting. Brain computed tomography showed a large, partially cystic, parieto-occipital lesion. The tumor was composed by glial fibrillary acidic protein-positive round cells with a perivascular arrangement and scattered neuropil-like islands, showing intense positivity for synaptophysin. Despite radiotherapy, the tumor recurred, showing frank features of anaplasia, but lacking the neuropil-like islands. The histological features of the tumor are discussed in the light of the concept that neuronal differentiation can occur occasionally in gliomas of different lineage without affecting the expected biological behavior.
- Subjects
NEUROPILINS; CELL adhesion molecules; TOMOGRAPHY; TUMORS; MEDICAL radiography; MEDICAL electronics
- Publication
Acta Neuropathologica, 2005, Vol 109, Issue 2, p231
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-004-0927-y