We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
How Many Passes Are Needed for Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for Sarcoidosis? A Prospective Multicenter Study.
- Authors
Oki, Masahide; Saka, Hideo; Ando, Masahiko; Nakashima, Harunori; Shiraki, Akira; Murakami, Yasushi; Kogure, Yoshihito; Kitagawa, Chiyoe; Kato, Tatsuo
- Abstract
<bold><italic>Background:</italic></bold> While endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is widely used as an initial diagnostic procedure for pathological confirmation of sarcoidosis, it is unclear how many passes are required to obtain diagnostic materials. <bold><italic>Objectives:</italic></bold><italic></italic> The aim of this study was to determine the number of needle passes needed for the diagnosis of stage I/II sarcoidosis using EBUS-TBNA. <bold><italic>Methods:</italic></bold> At three institutions, 109 patients with suspected stage I/II sarcoidosis were recruited and underwent 6 passes of EBUS-TBNA for the main target lesion. Additional EBUS-TBNA for other lesions was permitted. The cumulative yields of needle passes for detecting noncaseating epithelioid cell granulomas were analyzed. <bold><italic>Results:</italic></bold> A total of 109 patients underwent EBUS-TBNA for 184 lesions. EBUS-TBNA identified specimens containing granulomas in 81 of 92 patients (88%) with a final diagnosis of sarcoidosis. The cumulative yields through the first, second, third, fourth, fifth, and sixth passes for the main target lesion were 63, 75, 82, 85, 86 and 88%, respectively. In the 55 patients that underwent EBUS-TBNA for multiple lesions, the cumulative yields of 2 passes per lesion for 2 lesions (total of 4 passes) and of 4 passes for single lesions were 86 and 84%, respectively (<italic>p</italic> = 1.00). <bold><italic>Conclusions:</italic></bold> If rapid on-site cytological evaluation is not available, we recommend at least 4 passes per patient for either single or multiple lesions with EBUS-TBNA for pathological diagnosis of stage I/II sarcoidosis.
- Subjects
LONGITUDINAL method; MEDICAL cooperation; NEEDLE biopsy; RESEARCH; SARCOIDOSIS
- Publication
Respiration, 2018, Vol 95, Issue 4, p251
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000485661