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- Title
Risk of Ovarian Cancer in BRCA1 and BRCA2 Mutation-Negative Hereditary Breast Cancer Families.
- Authors
Kauff, Noah D.; Mitra, Nandita; Robson, Mark E.; Hurley, Karen E.; Chuai, Shaokun; Goldfrank, Deborah; Wadsworth, Eve; Lee, Johanna; Cigler, Tessa; Borgen, Patrick I.; Norton, Larriy; Barakat, Richard R.; Offit, Kenneth
- Abstract
Women from site-specific hereditary breast cancer families who carry a BRCA1 or BRCA2 mutation are at increased risk for ovarian cancer. It is less clear, however, whether individuals from hereditary breast cancer families who do not carry such a mutation are also at increased ovarian cancer risk. To determine whether women from BRCA mutation-negative hereditary breast cancer families are at increased risk for ovarian cancer, 199 probands from BRCA mutation-negative, site-specific breast cancer kindreds who consented to prospective follow-up at the time of genetic testing were identified. The incidence of new breast and ovarian cancers in probands and their families since receipt of their genetic test results was determined by questionnaire. The expected number of cancers and standardized incidence ratios (SIRs) were determined from age-specific cancer incidence rates from the Surveillance, Epidemiology, and End Results (SEER) program by using the method of Byar. All statistical tests were two-sided. During 2534 women-years of follow-up in 165 kindreds, 19 new cases of breast cancer were diagnosed, whereas only 6.07 were expected (SIR = 3.13, 95% confidence interval [CI] = 1.88 to 4.89; P«.001), and one case of ovarian cancer was diagnosed, whereas only 0.66 was expected (SIR = 1.52, 95% CI = 0.02 to 8.46; P = .48). These results suggest that women from BRCA mutation-negative, site-specific breast cancer families are not at increased risk for ovarian cancer.
- Subjects
OVARIAN diseases; GYNECOLOGIC cancer; CANCER risk factors; CHROMOSOME abnormalities; BREAST cancer; CANCER in women; FAMILIAL diseases; GENETICS
- Publication
JNCI: Journal of the National Cancer Institute, 2005, Vol 97, Issue 18, p1382
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/dji281