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- Title
Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation study.
- Authors
Beckett WS; Chalupa DF; Pauly-Brown A; Speers DM; Stewart JC; Frampton MW; Utell MJ; Huang L; Cox C; Zareba W; Oberdörster G; Beckett, William S; Chalupa, David F; Pauly-Brown, Andrea; Speers, Donna M; Stewart, Judith C; Frampton, Mark W; Utell, Mark J; Huang, Li-Shan; Cox, Christopher
- Abstract
<bold>Rationale: </bold>Zinc oxide is a common, biologically active constituent of particulate air pollution as well as a workplace toxin. Ultrafine particles (< 0.1 microm diameter) are believed to be more potent than an equal mass of inhaled accumulation mode particles (0.1-1.0 microm diameter).<bold>Objectives: </bold>We compared exposure-response relationships for respiratory, hematologic, and cardiovascular endpoints between ultrafine and accumulation mode zinc oxide particles.<bold>Methods: </bold>In a human inhalation study, 12 healthy adults inhaled 500 microg/m3 of ultrafine zinc oxide, the same mass of fine zinc oxide, and filtered air while at rest for 2 hours.<bold>Measurements and Main Results: </bold>Preexposure and follow-up studies of symptoms, leukocyte surface markers, hemostasis, and cardiac electrophysiology were conducted to 24 hours post-exposure. Induced sputum was sampled 24 hours after exposure. No differences were detected between any of the three exposure conditions at this level of exposure.<bold>Conclusions: </bold>Freshly generated zinc oxide in the fine or ultrafine fractions inhaled by healthy subjects at rest at a concentration of 500 microg/m3 for 2 hours is below the threshold for acute systemic effects as detected by these endpoints.
- Publication
American Journal of Respiratory & Critical Care Medicine, 2005, Vol 171, Issue 10, p1129
- ISSN
1073-449X
- Publication type
journal article
- DOI
10.1164/rccm.200406-837oc