We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Assessment of the level of vaccine-induced anti-HBs antibodies in children with inflammatory systemic connective tissue diseases treated with immunosuppression.
- Authors
Szczygielska, Izabela; Hernik, Elżbieta; Kwiatkowska, Małgorzata; Rutkowska-Sak, Lidia; Kołodziejczyk, Beata; Gazda, Agnieszka
- Abstract
Objectives: Protective vaccinations are the most effective method of prevention of type B virus hepatitis. The aim of the study was to determine whether in children receiving immunosuppressive therapy due to inflammatory systemic connective tissue diseases the protective concentration of the anti-HBs antibodies produced after vaccination against type B virus hepatitis in infancy is maintained. Material and methods: The concentration of anti-HBs antibodies was assessed in the sera of 50 children with inflammatory connective tissue diseases - 37 girls (74%) and 13 boys (26%), aged 1.5-17.5 years - during the immunosuppressive treatment, which lasted at least 6 months. The control group consisted of 50 healthy children - 28 girls (56%) and 22 boys (44%) aged 2-17 years. All children were vaccinated in infancy with Engerix B vaccine according to the 0-1-6 months schedule. The antibody concentration of = 10 mIU/ml in patients is regarded as protective. Results: No protective antibody concentrations were found in 25 cases (50%) in the group of diseased children and only in 2 children in the control group (4%). Conclusions: The concentration of vaccine-induced antibodies should be assessed in children with inflammatory systemic connective tissue diseases and, in case of the absence of a protective concentration, revaccination should be started. The use of glucocorticosteroids, synthetic and biological disease-modifying antirheumatic drugs is no contraindication to vaccination against hepatitis B.
- Subjects
HEPATITIS B vaccines; CONNECTIVE tissue diseases in children; HEPATITIS B -- Immunological aspects; IMMUNOSUPPRESSION; GLUCOCORTICOIDS; ANTIRHEUMATIC agents; THERAPEUTICS
- Publication
Rheumatology / Reumatologia, 2015, Vol 53, Issue 2, p56
- ISSN
0034-6233
- Publication type
Article
- DOI
10.5114/reum.2015.51503