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- Title
Efficacy of Individualized Homeopathic Medicines in the Treatment of Atopic Dermatitis in Adults: A Double-Blind, Randomized, Placebo-Controlled, Preliminary Trial.
- Authors
Dey, Samit; Shaikh, Abdur Rahaman; Saha, Sangita; Agrawal, Ekta; Gautam, Ashish Kumar; Karuppusamy, Avaranjika; Sadhukhan, Satarupa; Dutta, Souvik; Ali, Sk. Swaif; Basu, Anamika; Koley, Munmun; Saha, Subhranil
- Abstract
Introduction: Individualized homeopathy (IH) in atopic dermatitis (AD) remained under-researched. Objective: We aimed at evaluating efficacy of IH in AD. Methods: A double-blind, randomized, placebo-controlled, short-term, preliminary trial was conducted in an Indian homeopathy hospital. Patients were randomized to either IH (n = 30) or identical-looking placebo (n = 30) using computerized randomization and allocation. Outcomes were patient-oriented scoring of AD (PO-SCORAD; primary end point), Dermatological Life Quality Index (DLQI) score, and AD burden score for adults (ADBSA; secondary end points), measured monthly for 3 months. An intention-to-treat sample was analyzed after adjusting baseline differences. Results: On PO-SCORAD, improvement was higher in IH against placebo, but nonsignificant statistically (pmonth 1 = 0.433, pmonth 2 = 0.442, pmonth 3 = 0.229). Secondary outcomes were also nonsignificant – both DLQI and ADBSA (p > 0.05). Four adverse events (diarrhea, injury, common cold) were recorded. Conclusions: There was a small, but nonsignificant direction of effect towards homeopathy, which renders the trial inconclusive. A properly powered robust trial is indicated.
- Publication
Complementary Medicine Research, 2022, Vol 29, Issue 1, p17
- ISSN
2504-2092
- Publication type
Article
- DOI
10.1159/000516026