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- Title
基质金属蛋白酶 / 基质金属蛋白酶水解酶对肝纤维化的 调控及相关治疗药物研究进展.
- Authors
黄倩; 杨燕; 曾锐; 姚孟林; 孙琴
- Abstract
Liver fibrosis is the common consequence of various chronic liver injuries and is mainly characterized by the imbalance between the production and degradation of extracellular matrix, which leads to the accumulation of interstitial collagen and other matrix components. Matrix metalloproteinases ( MMPs) and their specific inhibitors, i.e., tissue inhibitors of metalloproteinases ( TIMPs), play a crucial role in collagen synthesis and lysis. Through a literature review, this article reviews the experimental studies of liver fibrosis based on MMPs/ TIMPs, summarizes the components that may exert an anti - liver fibrosis effect by affecting the expression or activity of MMPs/TIMPs, and attempts to clarify the mechanism of MMPs/TIMPs in regulating collagen homeostasis, so as to provide support for the development of anti - liver fibrosis drugs.
- Publication
Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, 2022, Vol 38, Issue 6, p1420
- ISSN
1001-5256
- Publication type
Article
- DOI
10.3969/j.issn.1001-5256.2022.06.042