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- Title
Elevated cerebrospinal fluid uric acid during relapse of neuromyelitis optica spectrum disorders.
- Authors
Shu, Yaqing; Li, Haiyan; Zhang, Lei; Wang, Yuge; Long, Youming; Li, Rui; Qiu, Wei; Lu, Zhengqi; Hu, Xueqiang; Peng, Fuhua
- Abstract
Introduction Previous studies have shown that serum uric acid ( UA) modulates outcomes of neurological diseases, although little is known about cerebrospinal fluid ( CSF) UA levels in neuromyelitis optica spectrum disorders ( NMOSDs). Methods Cerebrospinal fluid and serum UA levels were measured in samples from 68 patients, including NMOSDs during relapse ( n = 38) and controls with noninflammatory and non-neurodegenerative diseases ( CTLs, n = 30). Correlation analysis was performed between CSF UA and clinical characteristics, serum UA, and blood-brain barrier integrity in NMOSDs. Results Cerebrospinal fluid UA levels in NMOSDs were significantly higher than in CTLs ( p = .002), while serum UA differences between NMOSDs and CTLs were not statistically significant. In NMOSDs, CSF UA levels were significantly higher in patients with an impaired blood-brain barrier than in patients with an intact one ( p < .001), and significantly higher in longer disease duration than in shorter disease duration patients ( p = .002). CSF UA levels were also significantly higher in active patients upon MRI than in inactive patients ( p < .001), and significantly higher in patients with brain lesions than without brain lesions ( p = .024). CSF UA was significantly associated with the serum UA levels ( r = .454, p = .002), disease duration ( r = .383, p = .018), and blood-brain barrier index ( r = .805, p < .001), but did not correlate with age, gender, annualized relapse rate, duration, or severity of NMOSD. Multiple regression analysis demonstrated that CSF UA was independent of the blood-brain barrier index (β = .765, p < .001) and serum UA levels (β = .01, p = .019) in NMOSDs. Conclusions Cerebrospinal fluid UA levels were elevated in NMOSD patients during relapse, and were likely modified by serum UA levels and blood-brain barrier integrity.
- Subjects
NEUROLOGICAL disorders; BRAIN diseases; URIC acid; NEUROMYELITIS optica; PATHOLOGICAL psychology; THERAPEUTICS
- Publication
Brain & Behavior, 2017, Vol 7, Issue 1, pn/a
- ISSN
2162-3279
- Publication type
Article
- DOI
10.1002/brb3.584