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- Title
Usefulness of daily surveillance blood cultures in allogeneic hematopoietic stem cell transplant recipients on steroids: a 1-year prospective study.
- Authors
Colombier, M.‐A.; Lafaurie, M.; Fontbrune, F.S.; Resche‐Rigon, M.; Donay, J.‐L.; Pons, J.‐L.; Molina, J.‐M.; Socie, G.
- Abstract
Background Bloodstream infections ( BSI) are frequent and potentially severe complications in allogeneic hematopoietic stem cell transplant ( AHSCT) recipients. In patients on steroids, surveillance blood cultures ( SBCs) are routinely performed to detect asymptomatic BSI but their usefulness remains controversial. Methods We performed a 1-year, observational, prospective, single-center study to assess the utility of daily SBCs in AHSCT recipients on steroids and a case-control study to identify risk factors associated with positive SBCs. All blood cultures ( BCs) obtained from adults hospitalized in the HSCT unit were prospectively studied throughout 1 year. Characteristics, treatments, and outcome of patients were retrieved from medical charts. Results A total of 3594 BCs were obtained in 177 patients, including 1450 SBCs in 82 AHSCT recipients on steroids. In 33 patients, 103 SBCs (7%) were positive. Low-virulence bacteria were identified in 74% of episodes. When analyzing first episode of positive SBCs (28 patients), 6 (21%) true BSI were identified. Conclusions Patients with positive SBCs were receiving antibiotic treatment less frequently at the time of SBCs ( P < 0.001) and had more frequently BCs obtained through central venous access ( P < 0.04) when compared to patients with negative SBCs. Daily SBCs in AHSCT recipients on steroids only rarely identify BSI and clear benefit for patients could not be demonstrated.
- Subjects
HEMATOPOIETIC stem cell transplantation; STEROIDS; BLOOD testing; CASE-control method; MICROBIAL virulence
- Publication
Transplant Infectious Disease, 2016, Vol 18, Issue 4, p504
- ISSN
1398-2273
- Publication type
Article
- DOI
10.1111/tid.12552