We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Biomarkers in Cutaneous Keratinocyte Carcinomas.
- Authors
Montano, Erica; Bhatia, Neal; Ostojić, Jelena
- Abstract
Skin cancer is the most common cancer type in the USA, with over five million annually treated cases and one in five Americans predicted to develop the disease by the age of 70. Skin cancer can be classified as melanoma or non-melanoma (NMSC), the latter including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC). Development of BCC and SCC is impacted by environmental, behavioral, and genetic risk factors and the incidence is on the rise, with the associated number of deaths surpassing those caused by melanoma, according to recent reports. Substantial morbidity is related to both BCC and SCC, including disfigurement, loss of function, and chronic pain, driving high treatment costs, and representing a heavy financial burden to patients and healthcare systems worldwide. Clinical presentations of BCC and SCC can be diverse, sometimes carrying considerable phenotypic similarities to benign lesions, and underscoring the need for the development of disease-specific biomarkers. Skin biomarker profiling plays an important role in deeper disease understanding, as well as in guiding clinical diagnosis and patient management, prompting the use of both invasive and non-invasive tools to evaluate specific biomarkers. In this work, we review the known and emerging biomarkers of BCC and SCC, with a focus on molecular and histologic biomarkers relevant for aspects of patient management, including prevention/risk assessments, tumor diagnosis, and therapy selection.
- Subjects
SKIN cancer; BASAL cell carcinoma; BIOMARKERS; KERATINOCYTES; CARCINOMA; SQUAMOUS cell carcinoma
- Publication
Dermatology & Therapy, 2024, Vol 14, Issue 8, p2039
- ISSN
2193-8210
- Publication type
Article
- DOI
10.1007/s13555-024-01233-w