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- Title
NK-1 Receptor Antagonists and Pruritus: Review of Current Literature.
- Authors
Pojawa-Gołąb, Marcelina; Jaworecka, Kamila; Reich, Adam
- Abstract
The discovery of the first neurokinin 1 (NK-1) receptor antagonist was a turning point in the prevention of chemotherapy-induced nausea and vomiting. The NK-1 antagonists are a novel class of drugs that possess antidepressant, anxiolytic, and antiemetic properties. Recently, clinicians have also described an anti-itch activity of NK-1 antagonists. We present herein results from currently available data on use of NK-1R antagonists in dermatology. For this purpose, a systemic electronic literature search of the PubMed and CINAHL databases, Cochrane Library, and clinicaltrials.gov website was performed. Based on currently available data, it can be concluded that NK-1 inhibitors show significant antipruritic potential for treatment of chronic pruritus in different dermatological conditions, but further studies are needed to establish the best indications and dosage of these drugs.
- Subjects
ITCHING; SUBSTANCE P receptors; CHEMICAL inhibitors; THERAPEUTICS
- Publication
Dermatology & Therapy, 2019, Vol 9, Issue 3, p391
- ISSN
2193-8210
- Publication type
Article
- DOI
10.1007/s13555-019-0305-2