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- Title
Effects of aerobic and resistance training of long duration on pro- and anti-inflammatory cytokines in rats.
- Authors
Silva, C. M. S.; Vieira-Junior, R. C.; Trombeta, J. C. R.; Lima, T. R.; Fraga, G. A.; Sena, M. S.; Ávila, E. T. P.; Tibana, R. A.; Prestes, J.; Navalta, J. W.; Voltarelli, F. A.
- Abstract
Objective: To determine possible changes in serum concentrations of pro- and anti-inflammatory cytokines of eutrophic rats subjected to aerobic or resistance physical training. Methods: This study examined serum concentrations of TNF-α, IFN-γ, IL-6, IL-10 and IL-1-β in rats that performed aerobic or resistance training for 16 weeks. Thirty-five Wistar rats (male adult) were divided into three groups: Control Group (CG), Aerobic Group (AG) and Resistance Group (RG). Rats were sacrificed 48 h after the final training session. Serum concentrations of cytokines were analysed by ELISA. Results: TNF-α levels were higher in the RG. followed by the AG and CG groups (p<0.001). IFN-γ and IL-10 levels were not significantly different between groups (p = 0.097 and p = 0.17, respectively). The levels of IL6 and IL1-γ were higher in AG compared to RG and CG (p = 0.0004 and p = 0.003, respectively). In general, our results indicate a higher pro-inflammatory profile in AG and probably RG animals. Conclusion: Further studies are required in order to better clarify the effects of aerobic and resistance exercise training on pro- and anti-inflammatory cytokines. Additionally, future studies should address the metabolic and molecular pathways involved in these responses.
- Subjects
AEROBIC exercises; ANTI-inflammatory agents; LABORATORY rats
- Publication
Revista Andaluza de Medicina del Deporte, 2017, Vol 10, Issue 4, p170
- ISSN
1888-7546
- Publication type
Article
- DOI
10.1016/j.ramd.2016.02.005