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- Title
Brain Injury and Cerebrovascular Fibrin Deposition Correlate With Reduced Antithrombotic Brain Capillary Functions in a Hypertensive Stroke Model.
- Authors
Ninomia, Takashi; Wang, Liang; Kumar, S Ram; Kim, Anthony; Zlokovic, Berislav V
- Abstract
Summary:Hemostasis factors may influence the pathophysiology of stroke. The role of brain hemostasis in ischemic hypertensive brain injury is not known. We studied ischemic injury in spontaneously hypertensive rats in relation to cerebrovascular fibrin deposition and activity of different hemostasis factors in brain microcirculation. In spontaneously hypertensive rats subjected to transient middle cerebral artery occlusion versus normotensive Wistar-Kyoto (W-K) rats, infarct and edema volumes were increased by 6.1-fold (P < 0.001) and 5.8-fold (P < 0.001), respectively, the cerebral blood flow (CBF) reduced during middle cerebral artery occlusion (MCAO) by 55% (P < 0.01), motor neurologic score increased by 6.9-fold (P < 0.01), and cerebrovascular fibrin deposition increased by 6.8-fold (P < 0.01). Under basal conditions, brain capillary protein C activation and tissue plasminogen activator activity were reduced in spontaneously hypertensive rats compared with Wistar-Kyoto rats by 11.8-fold (P < 0.001) and 5.1-fold (P < 0.001), respectively, and the plasminogen activator inhibitor-1 antigen and tissue factor activity were increased by 154-fold (P < 0.00001) and 74% (P < 0.01), respectively. We suggest that hypertension reduces antithrombotic mechanisms in brain microcirculation, which may enhance cerebrovascular fibrin deposition and microvascular obstructions during transient focal cerebral ischemia, which results in greater neuronal injury.Journal of Cerebral Blood Flow & Metabolism (2000) 20, 998-1009; doi:10.1097/00004647-200006000-00012
- Publication
Journal of Cerebral Blood Flow & Metabolism, 2000, Vol 20, Issue 6, p998
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1097/00004647-200006000-00012