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- Title
The Cerebral Metabolic Consequences of Nitric Oxide Synthase Deficiency: Glucose Utilization in Endothelial and Neuronal Nitric Oxide Synthase Null Mice.
- Authors
Browne, Susan E; Ayata, Cenk; Huang, Paul L; Moskowitz, Michael A; Beal, M Flint
- Abstract
SummaryNitric oxide has multiple physiologic roles in the CNS. Inhibiting nitric oxide synthesis might therefore alter functional activity within the brain. We used [14C]-2-deoxyglucose in vivo autoradiography to measure local CMRglc in 'knockout' mice lacking the genes for either the endothelial (eNOS) or neuronal (nNOS) isoforms of nitric oxide synthase, and in the progenitor strains (SV129, C57B1/6). Glucose utilization levels did not significantly differ between nNOS and eNOS knockout mice and C57Bl/6 mice in any of the 48 brain regions examined, but were relatively lower in some subcortical regions in SV129 mice.Journal of Cerebral Blood Flow & Metabolism (1999) 19, 144-148; doi:10.1097/00004647-199902000-00005
- Publication
Journal of Cerebral Blood Flow & Metabolism, 1999, Vol 19, Issue 2, p144
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1097/00004647-199902000-00005