We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
cAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasis.
- Authors
D. Wu; H. E. Zhau; W.-C. Huang; S. Iqbal; Habib, F. K.; Sartor, O.; Cvitanovic, L.; Marshall, F. F.; Z. Xu; L. W. K. Chung
- Abstract
Aberrant expression of vascular endothelial growth factor (VEGF) is associated with human prostate cancer (PCa) metastasis and poor clinical outcome. We found that both phosphorylation of cyclic AMP-responsive element-binding protein (CREB) and VEGF levels were significantly elevated in patient bone metastatic PCa specimens. A PCa ARCaP progression model demonstrating epithelial-to-mesenchymal transition exhibited increased CREB phosphorylation and VEGF expression as ARCaP cells became progressively more mesenchymal and bone-metastatic. Activation of CREB induced, whereas inhibition of CREB blocked, VEGF expression in ARCaP cells. CREB may regulate VEGF transcription via a hypoxia-inducible factor-dependent mechanism in normoxic conditions. Activation of CREB signaling is involved in the coordinated regulation of VEGF and may pre-dispose to PCa bone metastasis.Oncogene (2007) 26, 5070–5077; doi:10.1038/sj.onc.1210316; published online 19 February 2007
- Subjects
VASCULAR endothelial growth factors; PROSTATE cancer; GROWTH factors; CELLULAR control mechanisms; REGULATION of cell growth; CANCER invasiveness; CANCER patients
- Publication
Oncogene, 2007, Vol 26, Issue 35, p5070
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1210316