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- Title
Zinc May Have a Physiological Role in Regulating Pituitary Prolactin Secretion.
- Authors
Login, Ivan S.; Thorner, Michael O.; MacLeod, Robert M.
- Abstract
We studied the in vitro influence of physiologically relevant zinc concentrations on the pituitary synthesis and secretion of prolactin (Prl). Zinc in concentrations between 1 and 10 μM reduced Prl secretion and, to a milder extent, synthesis, but not basal or stimulated growth hormone (GH) or LH release. At a supraphysiological concentration of 100 μM, zinc markedly decreased Prl synthesis and secretion, but increased LH secretion. The ability of a physiological zinc concentration to influence Prl secretion suggests that this trace element may have a role in the in vivo regulation of Prl release. Copyright © 1983 S. Karger AG, Basel
- Publication
Neuroendocrinology, 1983, Vol 37, Issue 5, p317
- ISSN
0028-3835
- Publication type
Article
- DOI
10.1159/000123568