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- Title
Time-Course of the Effect of α-Methyl-p-Tyrosine on ACTH Secretion.
- Authors
Scapagnini, U.; Annunziato, L.; Lombardi, G.; Oliver, Ch.; Preziosi, P.
- Abstract
250 mg/kg i.p. of the methyl ester of α-methyl-p-tyrosine (α-MpT) produced a rapid increase (by 1 h) in immunoreactive plasma ACTH, whereas the hypothalamic norepinephrine (NE) concentration and plasma corticosterone (B) changed significantly only 6 h after the administration of the inhibitor. These data suggest that the norepinephrinergic inhibitory tonus of CRF-ACTH secretion depends on the availability of a rapidly utilized pool of transmitter, affected in a very short time by α-MpT. Copyright © 1975 S. Karger AG, Basel
- Publication
Neuroendocrinology, 1975, Vol 18, Issue 3, p272
- ISSN
0028-3835
- Publication type
Article
- DOI
10.1159/000122406