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- Title
Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [<sup>18</sup>F]Fluoromisonidazole ([<sup>18</sup>F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements.
- Authors
Kelada, Olivia; Rockwell, Sara; Zheng, Ming-Qiang; Huang, Yiyun; Liu, Yanfeng; Booth, Carmen; Decker, Roy; Oelfke, Uwe; Carson, Richard; Carlson, David; Kelada, Olivia J; Booth, Carmen J; Decker, Roy H; Carson, Richard E; Carlson, David J
- Abstract
<bold>Purpose: </bold>The purpose of this study is to use dynamic [18F]fluoromisonidazole ([18F]FMISO) positron emission tomography (PET) to compare estimates of tumor hypoxic fractions (HFs) derived by tracer kinetic modeling, tissue-to-blood ratios (TBR), and independent oxygen (pO2) measurements.<bold>Procedures: </bold>BALB/c mice with EMT6 subcutaneous tumors were selected for PET imaging and invasive pO2 measurements. Data from 120-min dynamic [18F]FMISO scans were fit to two-compartment irreversible three rate constant (K 1, k 2, k 3) and Patlak models (K i). Tumor HFs were calculated and compared using K i, k 3, TBR, and pO2 values. The clinical impact of each method was evaluated on [18F]FMISO scans for three non-small cell lung cancer (NSCLC) radiotherapy patients.<bold>Results: </bold>HFs defined by TBR (≥1.2, ≥1.3, and ≥1.4) ranged from 2 to 85 % of absolute tumor volume. HFs defined by K i (>0.004 ml min cm-3) and k 3 (>0.008 min-1) varied from 9 to 85 %. HF quantification was highly dependent on metric (TBR, k 3, or K i) and threshold. HFs quantified on human [18F]FMISO scans varied from 38 to 67, 0 to 14, and 0.1 to 27 %, for each patient, respectively, using TBR, k 3, and K i metrics.<bold>Conclusions: </bold>[18F]FMISO PET imaging metric choice and threshold impacts hypoxia quantification reliability. Our results suggest that tracer kinetic modeling has the potential to improve hypoxia quantification clinically as it may provide a stronger correlation with direct pO2 measurements.
- Subjects
TUMOR diagnosis; BIOMARKERS; FLUOROACETIC acid; POSITRON emission tomography; EMISSION tomography equipment; OXYGEN in the body; HYPOXEMIA; DIAGNOSIS; OXYGEN metabolism; ANIMAL experimentation; ANTHROPOMETRY; CELL lines; CELL physiology; COMPUTED tomography; DYNAMICS; IMIDAZOLES; MICE; MUSCLES; RESEARCH funding; TUMORS
- Publication
Molecular Imaging & Biology, 2017, Vol 19, Issue 6, p893
- ISSN
1536-1632
- Publication type
journal article
- DOI
10.1007/s11307-017-1083-9