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- Title
Breast cancer dormancy is associated with a 4NG1 state and not senescence.
- Authors
Prunier, Chloé; Alay, Ania; van Dijk, Michiel; Ammerlaan, Kelly L.; van Gelderen, Sharon; Marvin, Dieuwke L.; Teunisse, Amina; Slieker, Roderick C.; Szuhai, Karoly; Jochemsen, A. G.; Solé, Xavier; ten Dijke, Peter; Ritsma, Laila
- Abstract
Reactivation of dormant cancer cells can lead to cancer relapse, metastasis, and patient death. Dormancy is a nonproliferative state and is linked to late relapse and death. No targeted therapy is currently available to eliminate dormant cells, highlighting the need for a deeper understanding and reliable models. Here, we thoroughly characterize the dormant D2.OR and ZR-75-1, and proliferative D2A1 breast cancer cell line models in vivo and/or in vitro, and assess if there is overlap between a dormant and a senescent phenotype. We show that D2.OR but not D2A1 cells become dormant in the liver of an immunocompetent model. In vitro, we show that D2.OR and ZR-75-1 cells in response to a 3D environment or serum-free conditions are growth-arrested in G1, of which a subpopulation resides in a 4NG1 state. The dormancy state is reversible and not associated with a senescence phenotype. This will aid future research on breast cancer dormancy.
- Subjects
BREAST cancer; CANCER cells; DORMANCY (Biology); OLD age; PHENOTYPES
- Publication
NPJ Breast Cancer, 2021, Vol 7, Issue 1, p1
- ISSN
2374-4677
- Publication type
Article
- DOI
10.1038/s41523-021-00347-0