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- Title
Rapid and Practical Synthesis of gem‐Dibromoalkanes from Aldehydes by Tribromide Reagent.
- Authors
Ren, Bowen; Xu, Jianeng; Liu, Chao
- Abstract
gem‐Dibromoalkanes are important synthetic building block in organic chemistry, but their preparation is still troublesome. Herein, we have developed a simple and practical protocol for the synthesis of gem‐dibromoalkanes from aldehydes using tetrabutylammonium tribromide and triphenyl phosphite. A variety of alkyl and aromatic aldehydes can be transformed into the corresponding products within 10 minutes. This protocol is also applicable to alcohols, and the configuration of chiral alcohol is inverted during the process with excellent enantiopurity.
- Subjects
ALDEHYDES; ORGANIC chemistry; ALKYL bromides
- Publication
Chemistry - An Asian Journal, 2024, Vol 19, Issue 5, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202301087