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- Title
Ultraviolet/Visible Light Regulated Protein Transport Gate Constructed by Pillar[6]arene‐based Host‐Guest System.
- Authors
Yang, Lei; Zhang, Fan; Chen, Chunxiu; Liu, Zhisheng; Liu, Lu; Li, Haibing
- Abstract
Protein transport is an interesting and intrinsic life feature that is highly relevant to physiology and disease in living beings. Herein, inspired by nature, based on the supramolecular host‐guest interaction, we have introduced the classical azobenzene light switches and L‐phenylalanine derived pillar[6]arene (L‐Phe‐P6) into the artificial nanochannel to construct light‐responsive nanochannels that could regulate protein transport effectively under the control of ultraviolet (UV) and visible (Vis) light. The light‐controlled distribution of L‐Phe‐P6 in the channel led to the difference in surface charges in the nanochannel, which eventually brought the difference in protein transport. This research may not only provide a convenient theoretical model for biological research, but also a flexible light‐responsive protein transport model, which will play a crucial role in light‐controlled release of protein drugs and so on.
- Subjects
PROTEIN transport; CARRIER proteins; VISIBLE spectra; SURFACE charges; COLUMNS; PROTEIN models; SUPRAMOLECULAR polymers
- Publication
Chemistry - An Asian Journal, 2022, Vol 17, Issue 14, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202200455