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- Title
Nickel‐Catalyzed Heck‐Type Monofluoroacetation of Styrenes for Facile Synthesis of Allylic Fluorides.
- Authors
Wang, Zhen‐Yu; Wan, Jia‐Hao; Wang, Gao‐Yin; Jin, Ruo‐Xing; Lan, Quan; Wang, Xi‐Sheng
- Abstract
Abstract: An efficient nickel‐catalyzed Heck‐type reaction between styrenes and fluoroalkyl iodine has been developed. This novel transformation has demonstrated a broad substrate scope, mild reaction conditions and excellent <italic>E</italic>‐stereoselectivity. This efficient synthetic method has been applied to the late‐stage monofluoroacetation of biologically active molecules. Mechanistic investigations indicate that a monofluoroalkyl radical is involved in the catalytic cycle.
- Subjects
NICKEL catalysts; STYRENE; CHEMICAL synthesis; FLUORIDES; CHEMICAL reactions
- Publication
Chemistry - An Asian Journal, 2018, Vol 13, Issue 3, p261
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.201701655