We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Comprehensive Evaluation of Macrocytosis: A Prospective Observational Study.
- Authors
Gantayat, Chandan Kumar; Panigrahy, Biswakesh; Prachishree, Luzoo; Panda, Jagnyaseni
- Abstract
Background: Macrocytosis, characterized by abnormally large red blood cells (RBCs), often indicated by elevated Mean Corpuscular Volume (MCV) in complete blood count (CBC), is a significant hematological finding. Diverse underlying pathologies, including megaloblastic and non-megaloblastic etiologies, contribute to macrocytosis. Understanding these causes is crucial for tailored management strategies. Aim: This study aimed to delineate macrocytic anemia into megaloblastic and non-megaloblastic subtypes through comprehensive hematological and biochemical analyses. Additionally, it sought to evaluate distinctive hematological features among different etiologies in macrocytic patients. Methods: A prospective observational study was conducted from January 2021 to November 2021 at MKCG Medical College and Hospital, Odisha, India. 350 adult patients with MCV = 100 fl were enrolled, and comprehensive hematological and biochemical analyses were performed. Patients were categorized into megaloblastic and non-megaloblastic groups based on identified etiological factors. Results: Of the enrolled patients, 162 (46.29%) were diagnosed with megaloblastic anemia, while 188 (53.71%) presented with non-megaloblastic macrocytosis. Significant differences were observed in various hematological and biochemical parameters between the two groups. Excessive alcohol intake was the most prevalent etiology among non-megaloblastic macrocytosis cases. Discussion: The study highlights the importance of evaluating macrocytosis, even in the absence of anemia, emphasizing thorough assessment for accurate diagnosis. Megaloblastic anemia was primarily associated with deficiencies in vitamin B12 and folate, while non-megaloblastic macrocytosis had diverse underlying pathologies, including liver diseases and alcohol consumption. Conclusion: Comprehensive evaluation of macrocytosis is essential for accurate diagnosis and management. Further research is warranted to optimize diagnostic strategies for this clinically significant condition.
- Subjects
ODISHA (India); INDIA; VITAMIN B12 deficiency; BLOOD cell count; ERYTHROCYTES; LONGITUDINAL method; SCIENTIFIC observation; ALPHA 1-antitrypsin deficiency
- Publication
European Journal of Cardiovascular Medicine, 2024, Vol 14, Issue 1, p1070
- ISSN
2042-4884
- Publication type
Article