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- Title
MTHFR C677T POLYMORPHISM IN PATIENTS WITH CARDIOVASCULAR DISEASES IN BIHOR COUNTY.
- Authors
Maghiar, Adriana Laura; Bembea, Marius; Jurca, Claudia; Kozma, Kinga
- Abstract
The Polymorphism of MTHFR gene is associated in many studies with risk of cardiovascular disease. The purpose of the study was to determine the genotype of MTHFR 677 and establishing the correlation with cardiovascular disease in a group of patients in Bihor County. We conducted a case-control study on two equal groups of patients, a study group (SG) consisting of patients with acute myocardial infarction and thromboembolism and a control group (CG) consisting of a number of 51 healthy individuals coming from Bihor County. To the participants in both groups was performed the genotyping on gene MTHFR 677 through real-time PCR method. The proportion and significance of the three genotypes CC, CT and TT of the MTHFR 677 gene were analyzed by comparison in the two groups. The proportions found were: men of SG vs CG, MTHFR genotype C677C (wild type) was 22.86% vs. 40.67%; MTHFR C677T (heterozygous mutant) 40.0% vs. 45% and MTHFR T677T (homozygous mutant) 37.14% vs. 12.50%. Women of SG vs CG, MTHFR genotype C677C (wild type) was 31,25% vs. 40,74%; MTHFR C677T (heterozygous mutant) 43,75% vs. 51,85% and MTHFR T677T (homozygous mutant) 22,0% vs. 7,41%. T677T homozygous mutant genotype of MTHFR gene is present in a higher percentage of both women and men in the study group compared with the control group, suggesting its predisposing role to cardiovascular disease. In the presence of the mutant allele T the risk of disease increases on the carriers, both women and men.
- Subjects
ROMANIA; CARDIOVASCULAR diseases; MEDICAL genetics; CARDIOVASCULAR diseases risk factors; MYOCARDIAL infarction diagnosis; POLYMERASE chain reaction; PUBLIC health
- Publication
Analele Universitatii din Oradea, Fascicula Ecotoxicologie, Zootehnie si Tehnologii în Industria Alimentara, 2016, p148
- ISSN
1583-4301
- Publication type
Article