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- Title
Temporal Evolution of Nonlinear Dynamics in Ventricular Arrhythmia.
- Authors
Small, Michael; Yu, Dejin; Harrison, Robert G.; Clayton, Richard; Eftestøl, Trygve; Sunde, Kjetil; Steen, Petter Andreas
- Abstract
Ventricular fibrillation (VF) is a rapidly lethal cardiac arrhythmia and one of the leading causes of sudden death in many industrialized nations. VF appears at random, but is produced by a spatially extended excitable system. We generated VF-like "pseudo-ECG" signals from a numerical caricature of cardiac tissue of 100 × 100 × 50 elements. The VF-like "pseudo-ECG" signals represent the propagation and break-up of an excitation scroll wave under FitzHughNagumo dynamics. We use surrogate data and correlation dimension techniques to show that the dynamics observed in these computational simulations is consistent with the evolution of spontaneous VF in humans. Furthermore, we apply a novel adaptation of the traditional first return map technique to show that scroll wave break-up may be represented by a characteristic structural transition in the first return plot. The patterns and features identified by the first return mapping technique are found to be independent of the observation function and location. These methods offer insight into the evolution of VF and hint at potential new methods for diagnosis and analysis of this rapidly lethal condition. Ventricular fibrillation (VF) is a rapidly lethal cardiac arrhythmia and one of the leading causes of sudden death in many industrialized nations. VF appears at random, but is produced by a spatially extended excitable system. We generated VF-like "pseudo-ECG" signals from a numerical caricature of cardiac tissue of 100 × 100 × 50 elements. The VF-like "pseudo-ECG" signals represent the propagation and break-up of an excitation scroll wave under FitzHughNagumo dynamics. We use surrogate data and correlation dimension techniques to show that the dynamics observed in these computational simulations is consistent with the evolution of spontaneous VF in humans. Furthermore, we apply a novel adaptation of the traditional first return map technique to show that scroll wave break-up may be...
- Subjects
VENTRICULAR fibrillation; NONLINEAR mechanics
- Publication
International Journal of Bifurcation & Chaos in Applied Sciences & Engineering, 2001, Vol 11, Issue 10, p2531
- ISSN
0218-1274
- Publication type
Article
- DOI
10.1142/S0218127401003590