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- Title
Androgen receptor expression in endometrial carcinoma and its correlation with clinicopathologic features.
- Authors
Hashmi, Atif Ali; Hussain, Zubaida Fida; Qadri, Amna; Irfan, Muhammad; Ramzan, Sahar; Faridi, Naveen; Khan, Amir; Edhi, Muhammad Muzzammil
- Abstract
Objectives: Recent evidence suggests a role of androgen receptor expression as a prognostic and therapeutic biomarker in endometrial carcinoma, therefore in the present study we aimed to evaluate the frequency of androgen expression in different subtypes of endometrial carcinoma and its association with clinic-pathologic features. Results: 18/89 (20.2%) cases of endometrial carcinoma showed positive androgen receptor expression. On the other hand, low, moderate and high androgen receptor expression was noted in 7/89 (7.9%), 10/89 (11.2%) and 1/89 (1.1%) cases respectively. 15/77 (19.48%) of endometrioid cancers and 3/7 (42.28%) cases of serous carcinoma showed androgen receptor expression; while none of the cases of clear cell or carcinosarcoma revealed androgen receptor expression. No significant association of androgen receptor expression with various clinicopathologic features of endometrial carcinoma was noted. We found that a significant subset of endometrial cancers express androgen receptor especially a serous cancers; therefore we suggest that androgen receptor expression testing should be done in endometrial carcinoma.
- Subjects
ANDROGEN receptors; ENDOMETRIAL cancer; SEROUS fluids; CARCINOSARCOMAS; GENE expression; CANCER
- Publication
BMC Research Notes, 2018, Vol 11, Issue 1, pN.PAG
- ISSN
1756-0500
- Publication type
Article
- DOI
10.1186/s13104-018-3403-9