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- Title
False resurrections: Distinguishing regenerated from spared axons in the injured central nervous system.
- Authors
Oswald Steward; Binhai Zheng; Marc Tessier-Lavigne
- Abstract
Several recent studies report that axon regeneration can be induced in the mature mammalian nervous system by novel treatments or genetic manipulations. In assessing these reports, it is important to be mindful of the history of regeneration research, which is littered with the corpses of studies that reported regeneration that later proved incorrect. One important reason is the spared axon conundrum, in which axons that survive a lesion are mistakenly identified as having regenerated. Here, we illustrate the problem and propose criteria that may be used to identify regenerated vs. spared axons, focusing on the injured spinal cord. J. Comp. Neurol. 459:18, 2003. © 2003 Wiley-Liss, Inc.
- Subjects
NERVOUS system; AXONS; MAMMALS
- Publication
Journal of Comparative Neurology, 2003, Vol 459, Issue 1, p1
- ISSN
0021-9967
- Publication type
Article
- DOI
10.1002/cne.10593