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- Title
Hamamelitannin Analogues that Modulate Quorum Sensing as Potentiators of Antibiotics against Staphylococcus aureus.
- Authors
Vermote, Arno; Brackman, Gilles; Risseeuw, Martijn D. P.; Vanhoutte, Bieke; Cos, Paul; Van Hecke, Kristof; Breyne, Koen; Meyer, Evelyne; Coenye, Tom; Van Calenbergh, Serge
- Abstract
The modulation of bacterial communication to potentiate the effect of existing antimicrobial drugs is a promising alternative to the development of novel antibiotics. In the present study, we synthesized 58 analogues of hamamelitannin (HAM), a quorum sensing inhibitor and antimicrobial potentiator. These efforts resulted in the identification of an analogue that increases the susceptibility of Staphylococcus aureus towards antibiotics in vitro, in Caenorhabditis elegans, and in a mouse mammary gland infection model, without showing cytotoxicity.
- Subjects
QUORUM sensing; ENZYME inhibitors; ANTIBIOTICS; STAPHYLOCOCCUS aureus; CHEMICAL synthesis
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 22, p6551
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201601973