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- Title
Visible-Light-Triggered Drug Release from TiO<sub>2</sub> Nanotube Arrays: A Controllable Antibacterial Platfomr.
- Authors
Xu, Jingwen; Zhou, Xuemei; Gao, Zhida; Song, Yan‐Yan; Schmuki, Patrik
- Abstract
In this work, we use a double-layered stack of TiO2 nanotubes (TiNTs) to construct a visible-light-triggered drug delivery system. The key for visible light drug release is a hydrophobic cap on the nanotubes containing Au nanoparticles (AuNPs). The AuNPs allow for a photocatalytic scission of the hydrophobic chain under visible light. To demonstrate this principle, we loaded ampicillin (AMP) into the lower part of the TiO2 nanotube stack, triggered visiblelight- induced release, and carried out antibacterial studies. The release from the platform becomes most controllable if the drug is silane-grafted in the hydrophilic bottom layer for drug storage. Thus, visible light photocatalysis can also determine the release kinetics of the active drug from the nanotube wall.
- Subjects
DRUG delivery systems; TITANIUM oxide nanotubes; NANOTUBES; PHOTOCATALYSIS; GOLD nanoparticles
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 2, p593
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201508710