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- Title
Polyvinyl Alcohol as a Biocompatible Alternative for the Passivation of Gold Nanorods.
- Authors
Kinnear, Calum; Burnand, David; Clift, Martin J. D.; Kilbinger, Andreas F. M.; Rothen-Rutishauser, Barbara; Petri-Fink, Alke
- Abstract
The functionalization of gold nanorods (GNRs) with polymers is essential for both their colloidal stability and biocompatibility. However, a bilayer of the toxic cationic surfactant cetyl trimethylammonium bromide (CTAB) adsorbed on the nanorods complicates this process. Herein, we report on a strategy for the biocompatible functionalization of GNRs with a hydrophobic polymeric precursor, polyvinyl acetate, which is then transformed into its hydrophilic analogue, polyvinyl alcohol. This polymer was chosen due to its well-established biocompatibility, tunable "stealth" properties, tunable hydrophobicity, and high degree of functionality. The biocompatibility of the functionalized GNRs was tested by exposing them to primary human blood monocyte derived macrophages; the advantages of tunable hydrophobicity were demonstrated with the long-term stable encapsulation of a model hydrophobic drug molecule.
- Subjects
POLYVINYL alcohol; PASSIVATION; NANORODS; COLLOIDAL stability; BIOCOMPATIBILITY; SURFACE active agents; POLYVINYL acetate; MONOCYTES
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 46, p12613
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201404100