We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis.
- Authors
Akatsuki Kokaze; Mamoru Ishikawa; Naomi Matsunaga; Kanae Karita; Masao Yoshida; Tadahiro Ohtsu; Hirotaka Ochiai; Takako Shirasawa; Hinako Nanri; Nobuyuki Saga; Iichiro Ohtsu; Hiromi Hoshino; Yutaka Takashima
- Abstract
Background Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance. The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on erythrocytic parameters in male Japanese health check-up examinees. Methods A total of 436 men (mean age ± standard deviation, 54.1 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, an exploratory cross-sectional analysis assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on red blood cell counts, hematocrit and hemoglobin was conducted. Results For Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption, coffee consumption significantly decreased red blood cell counts (P for trend = 0.022) and hemoglobin (P for trend = 0.035). The risk of anemia, defined as hemoglobin of <14 g/dL, after the aforementioned adjustment, appeared to depend on coffee consumption (P for trend = 0.078), and the adjusted odds ratio for anemia was significantly higher in men who consumed ≥4 cups of coffee per day than in those who consumed <1 cup per day (odds ratio = 3.771, 95% confidence interval: 1.088 to 13.06, P = 0.036). For Mt5178A genotypic men, coffee consumption possibly reduced the risk of anemia (P for trend = 0.049). However, after the aforementioned adjustment, the statistical significance disappeared (P for trend = 0.137). Conclusions This exploratory cross-sectional analysis suggests that Mt5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters and the risk of anemia in male Japanese health check-up examinees.
- Subjects
COFFEE drinking; MITOCHONDRIAL DNA; HYPERTENSION risk factors; DYSLIPIDEMIA; ERYTHROCYTES; HEMATOCRIT; HEMOGLOBINS; BODY mass index; DISEASE risk factors
- Publication
Journal of Physiological Anthropology, 2014, Vol 33, Issue 1, p25
- ISSN
1880-6791
- Publication type
Article
- DOI
10.1186/1880-6805-33-37