We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effect of Morgana extract on Candida albicans and Trichomonas vaginalis growth in vitro.
- Authors
Nikoomanesh, Fatemeh; Ebrahimi, Mina; Sadraei, Javid; Roudbarmohammadi, Shahla
- Abstract
Introduction: Vaginitis is the most common gynecologic diseases of women throughout the world. The most common causes of vaginitis in symptomatic women are vaginal candidiasis (20-25%), Trichomoniasis (15-20%) and bacterial vaginosis (40-45%). Candida species are the most important infectious agents, Types resistant to common drugs are on the rise. Morgana peregrina grows in tropical and subtropical regions of the world and in Iran, it grows in Sistan and Baluchestan province. The seeds and oil of this plant have medicinal properties including antimicrobial, Anti-tumor and antiinflammatory. The aim of this study was to find an alternative medicine to treat candida albicans and Trichomonas vaginitis. The aim of this study was to investigate the anti-trichomonas and anticandida effects of acetone extracts of Moringa peregrina in vitro. Materials and Methods: C. albicans exposure to various concentration (2, 1, ... and 0/003 mg/ml) of acetone extracts of Moringa and the rate of proliferation yeast cell was examined by Minimum Inhibitory Concentration (MIC) of the extract for C. albicans (ATCC 10231). We used acetone extracts of Moringa peregrina at concentrations of 375, 750, ... 3000 and 4000 µg/ml for the treatment of trichomoniasis. We evaluated the effect of the extracts after 24 and 48 hours. The final number of viable parasites were determined by trypan blue staining and neobar lamella, and IC50 (50% Inhibitory Concentration) value was calculated. The cytotoxic effect of the extract on the mice macrophage cells was investigated. Result: The funding showed that yeast growth in 2 mg/ml of acetone extracts reduced approximately to (> 1%) and MIC value was 2 mg/ml for C. albicans. Comparison between treatment and control groups revealed a significant decrease in the viability of parasites in the treatment group at all concentrations after both 24 and 48 hours (P <0.05). After 24 hours the IC50 and SI values were calculated as 682 and 4.1 for parasite respectively. Conclusion: in this study, investigated of different concentration of acetone extracts of Moringa peregrine on inhibiting the growth of C. albicans and T. vaginalis. The observed result compared to previous studies showed the inhibitory effect of extracts Moringa extracts on the growth of Candida and Trichomonas. It can be the identification and isolation of active ingredients of the plant, may lead to use of this extract for the treatment of both infections in the future studies.
- Subjects
IRAN; CANDIDA albicans; CONFERENCES &; conventions; TRICHOMONAS vaginalis; VAGINA; PLANT extracts
- Publication
Current Medical Mycology, 2018, Vol 4, p164
- ISSN
2423-3439
- Publication type
Article
- DOI
10.18502/cmm.4.S1.2018.180