We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Comparison of placental blood microscopy and the ICT HRP2 rapid diagnostic test to detect placental malaria
- Authors
Aguilar, Ruth; Machevo, Sonia; Menéndez, Clara; Bardají, Azucena; Nhabomba, Augusto; Alonso, Pedro L.; Mayor, Alfredo
- Abstract
Abstract: Monitoring interventions to prevent malaria in pregnancy requires sensitive detection of placental infection. Rapid diagnostic tests (RDTs) are good candidates, but little information is available on their sensitivity on placental blood. We have evaluated the agreement (kappa coefficient) between microscopy and a Plasmodium falciparum histidine-rich protein 2 (HRP2)-based immuno-chromatographic test (ICT) on placental blood from 1151 women at delivery. Prevalences of placental infection by microscopy and RDT were 5.1% and 5.0%, respectively, showing 82.9% agreement (p<0.0001). Discordances were found at low parasitemias (<500 parasites/μL) or negative microscopy. The results suggest that the HRP2-RDTs from ICT diagnostics is a good alternative to microscopy for diagnosing placental malaria at delivery.
- Subjects
MALARIA diagnosis; PLACENTA diseases; MICROSCOPY; BLOOD testing; CHROMATOGRAPHIC analysis; SENSITIVITY analysis
- Publication
Transactions of the Royal Society of Tropical Medicine & Hygiene, 2012, Vol 106, Issue 9, p573
- ISSN
0035-9203
- Publication type
Article
- DOI
10.1016/j.trstmh.2012.05.001