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- Title
Anticancer drug distribution in lymph and blood during adjuvant chemotherapy after surgery for gastric carcinoma. A study with a combined preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil.
- Authors
Hanaue, Hitoshi; Kurosawa, Tsutomu; Kitano, Yoshiaki; Miyakawa, Sadaaki; Nemoto, Akihisa; Yamamoto, Hiroshi; Asagoe, Tatsuo; Takada, Tadahiro; Yasuda, Hideki; Shikata, Jun-Ichi; Hanaue, H; Kurosawa, T; Kitano, Y; Miyakawa, S; Nemoto, A; Yamamoto, H; Asagoe, T; Takada, T; Yasuda, H; Shikata, J
- Abstract
Previously the authors reported that the fat emulsion of 1-(2-tetrahydrofuryl)-5-fluorouracil, tegafur (FT-207), yielded significantly higher concentrations of tegafur in the lymph and plasma compared to tegafur enteric-coated granules (FT-G). However, the emulsification did not improve the metabolic conversion rate of tegafur to 5-fluorouracil (5-FU). A study was performed to assay the plasma and lymphatic concentrations of tegafur, 5-FU, and uracil in seven patients after radical surgery for gastric carcinoma who were given a combined oral preparation of FT-207 and uracil (UFT). Both lymph and plasma 5-FU levels after UFT were 20 times greater than those after FT-G, although FT-207 levels were not different. Patients given UFT showed significantly greater 5-FU and uracil concentrations in the lymph compared with the plasma. The results of this study suggest a potential use of UFT as an adjuvant postoperative chemotherapeutic agent for gastric carcinoma.
- Subjects
BIOTRANSFORMATION (Metabolism); COMBINATION drug therapy; COMBINED modality therapy; FLUOROURACIL; HETEROCYCLIC compounds; LYMPH; STOMACH tumors
- Publication
Cancer (0008543X), 1987, Vol 59, Issue 9, p1571
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19870501)59:9<1571::AID-CNCR2820590907>3.0.CO;2-9