We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The antiemetic efficacy of secobarbital and chlorpromazine compared to metoclopramide, diphenhydramine, and dexamethasone. A randomized trial.
- Authors
Richards, Paul D.; Flaum, Morris A.; Bateman, Marilyn; Kardinal, Carl G.; Richards, P D; Flaum, M A; Bateman, M; Kardinal, C G
- Abstract
The efficacy of secobarbital sodium plus chlorpromazine (SC) in the prevention of cisplatin induced emesis was compared to the combination of metoclopramide, diphenhydramine, and dexamethasone (MDD). Twenty-three patients were entered onto protocol. Eighteen were evaluable. Good to excellent antiemetic prophylaxis was obtained in 72% with MDD versus 17% with SC (P less than 0.01). Sedation and anticholinergic side effects were more common with SC. Extrapyramidal reactions were more commonly seen with MDD. Significantly more patients preferred the combination of metoclopramide, diphenhydramine, and dexamethasone (P less than 0.05).
- Publication
Cancer (0008543X), 1986, Vol 58, Issue 4, p959
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19860815)58:4<959::AID-CNCR2820580426>3.0.CO;2-Z