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- Title
Properdin factor B and acute lymphocytic leukemia (ALL).
- Authors
Budowle, Bruce; Acton, Ronald T.; Barger, Bruce O.; Blackstock, Rebecca; Crist, William; Go, Rodney C. P.; Humphrey, G. Bennett; Ragab, Abdel; Roper, Maryanne; Vietti, Teresa; Dearth, James; Budowle, B; Acton, R T; Barger, B O; Blackstock, R; Crist, W; Go, R C; Humphrey, G B; Ragab, A; Roper, M
- Abstract
One hundred-sixty-four ALL patients were compared to 545 controls for differences in phenotype and gene frequencies at the Properdin factor B locus. In addition, 90 of the ALL patients were immune phenotyped. A significant association with the Bf F allele and ALL was found, resulting in an estimated relative risk of 3.62. There was no difference in the Bf S phenotype between ALL patients and controls. However, those homozygous for the Bf S allele are at a significantly low risk of 0.30 for developing ALL. ALL patients with a non-B/T cell type were 2.5 times more likely to be Bf SS homozygotes; in contrast, those patients with the pre-B cell type were 2.5 more likely to be Bf FF homozygotes. These data suggest association of the Bf locus with an ALL protection and/or susceptibility gene(s).
- Publication
Cancer (0008543X), 1982, Vol 50, Issue 11, p2369
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19821201)50:11<2369::AID-CNCR2820501123>3.0.CO;2-S