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- Title
Osteosarcoma arising in heterotopic ossification of dermatomyositis: case report and review of the literature.
- Authors
Eckardt, Jeffrry J.; Ivins, John C.; Perry, Harold O.; Unni, Krishnan K.; Eckardt, J J; Ivins, J C; Perry, H O; Unni, K K
- Abstract
A patient with dermatomyositis developed malignant transformation of the benign interfascial heterotopic bone. This patient had classic childhood dermatomyositis at the age of 3 years, and the disease was arrested after a one-year course of corticosteroid therapy. Extensive subcutaneous calcinosis cutis and deep interfascial calcinosis were the residua of the disease. Twenty-eight years later, the patient developed a high-grade osteosarcoma within the benign intermuscular heterotopic calcification and ossification that had been previously documented at the age of 8 years by a roentgenogram and at the age of 16 years by biopsy. This case represents the first report of the association of osteosarcoma and dermatomyositis, and possibly the first well-documented case of malignant transformation of benign heterotopic bone.
- Publication
Cancer (0008543X), 1981, Vol 48, Issue 5, p1256
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19810901)48:5<1256::AID-CNCR2820480534>3.0.CO;2-4