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- Title
Identification and Characterization of Novel Dermal Thy-1 Antigen-Bearing Dendritic Cells in Murine Skin.
- Authors
Tamaki, Kunihiko; Yasaka, Nami; Chang, Chung-Hsing; Ohtake, Naoto; Saitoh, Atsushi; Nakamura, Koichiro; Furue, Masutaka
- Abstract
Using immunofluorescence on dermal sheets of mouse ear, we identified novel Thy-1+ dermal dendritic cells in murine skin. These cells are resistant to topical corticosteroid treatment. The number of these dermal Thy-1+ dendritic cells is not altered with aging of the mice or with 3 d of culture. Dermal Thy-1+ dendritic cells have melanosomes in their cytoplasm; hence, phagocytic activity is likely to be present. Double immunofluorescence revealed that most of these dermal Thy-1+ dendritic cells express CD45. Furthermore, conventional immunofluorescence and confocal laser scanning microscopic findings showed that most of these Thy-1+ dermal dendritic cells express &gammaδ and Vγ3 T-cell receptors. The relationship between these dermal Thy-1 dendritic cells and dendritic epidermal T cells is discussed.
- Subjects
DENDRITIC cells; ANTIGENS; IMMUNOFLUORESCENCE; ADRENOCORTICAL hormones; EPIDERMIS; T cells
- Publication
Journal of Investigative Dermatology, 1996, Vol 106, Issue 3, p571
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12344049