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- Title
Oral antibiotic use and early-onset colorectal cancer: findings from a case-control study using a national clinical database.
- Authors
McDowell, Ronald; Perrott, Sarah; Murchie, Peter; Cardwell, Christopher; Hughes, Carmel; Samuel, Leslie
- Abstract
<bold>Background: </bold>Antibiotic-induced gut dysbiosis has been associated with colorectal cancer (CRC) in older adults. This study will investigate whether an association exists between antibiotic usage and early-onset colorectal cancer (CRC), and also evaluate this in later-onset CRC for comparison.<bold>Methods: </bold>A case-control study was conducted using primary care data from 1999-2011. Analysis were conducted separately in early-onset CRC cases (diagnosed < 50 years) and later-onset cases (diagnosed ≥ 50 years). Conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (CI) for the associations between antibiotic exposure and CRC by tumour location, adjusting for comorbidities.<bold>Results: </bold>Seven thousands nine hundred and three CRC cases (445 aged <50 years) and 30,418 controls were identified. Antibiotic consumption was associated with colon cancer in both age-groups, particularly in the early-onset CRC cohort (<50 years: adjusted Odds Ratio (ORadj) 1.49 (95% CI 1.07, 2.07), p = 0·018; ≥50 years (ORadj (95% CI) 1.09 (1.01, 1.18), p = 0·029). Antibiotics were not associated with rectal cancer (<50 years: ORadj (95% CI) 1.17 (0.75, 1.84), p = 0.493; ≥50 years: ORadj (95% CI) 1.07 (0.96, 1.19), p = 0.238).<bold>Conclusion: </bold>Our findings suggest antibiotics may have a role in colon tumour formation across all age-groups.
- Subjects
PATHOGENESIS; CASE-control method; COLORECTAL cancer; ODDS ratio; ANTIBIOTICS
- Publication
British Journal of Cancer, 2022, Vol 126, Issue 6, p957
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/s41416-021-01665-7