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- Title
Nitroglycerin in the prevention of post-ERCP pancreatitis: a meta-analysis.
- Authors
Li-Ming Shao; Qing-Yu Chen; Miao-Yan Chen; Jian-Ting Cai; Shao, Li-Ming; Chen, Qing-Yu; Chen, Miao-Yan; Cai, Jian-Ting
- Abstract
The objective of this research paper is to evaluate the effect of prophylactic nitroglycerin in the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) by performing a meta-analysis of randomized controlled trials (RCTs). Electronic databases, including PubMed, EMBASE, the Cochrane library, and the Science Citation Index, were searched to retrieve relevant trials. Outcome measures were the incidence of PEP. Four RCTs, enrolling a total of 856 patients, were included. Meta-analysis of these trials indicated a significant association between the use of nitroglycerin and the reduction of PEP (RR 0.60; 95%CI: 0.39-0.92; P = 0.02). However, subsequent sensitive analysis failed to confirm that nitroglycerin was statistically superior to a placebo in reducing PEP (RR 0.68; 95%CI: 0.41-1.11; P = 0.12). Based on the limitations in this meta-analysis, prophylactic use of nitroglycerine for all patients who underwent ERCP is not recommended. Further clinical trials are required to confirm the effect of nitroglycerin in the prevention of PEP.
- Subjects
ENDOSCOPIC retrograde cholangiopancreatography; THERAPEUTIC use of nitroglycerin; CONDOMS; PANCREATITIS; META-analysis; RANDOMIZED controlled trials; DATABASES; EQUIPMENT &; supplies; PREVENTION; DUODENUM; NITROGLYCERIN; SYSTEMATIC reviews
- Publication
Digestive Diseases & Sciences, 2010, Vol 55, Issue 1, p1
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-008-0709-9