We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effect of obstructive sleep apnea on glucose metabolism.
- Authors
Koh, Han-Chow E.; van Vliet, Stephan; Chao Cao; Patterson, Bruce W.; Reeds, Dominic N.; Laforest, Richard; Gropler, Robert J.; Ju, Yo-El S.; Mittendorfer, Bettina
- Abstract
Background: Obstructive sleep apnea (OSA) is prevalent in people with obes ity and is a major risk factor for type 2 diabetes (T2D). The effect of OSA on metabolic function and the precise mechanisms (insulin resistance, ß-cell dysfunction, or both) responsible for the increased T2D risk in people with OSA are unknown. Design and methods: We used a two-stage hyperinsulinemic-euglycemic clamp procedur e in conjunction with stable isotopically labeled glucose and palmitate tracer infusions and 18F-fluorodeoxyglucose injection and positron emission tomography to quantify multi-organ insulin action and oral and intravenous tolerance tests to evaluate glucosestimulated insulin secretion in fifteen people with obesity and OSA and thirteen people with obesity without OSA. Results: OSA was associated with marked insulin resistance of adipose t issue triglyceride lipolysis and glucose uptake into both skeletal muscles and adipose tissue, whereas there wa s no significant difference between the OSA and control groups in insulin action on endogenous glucose producti on, basal insulin secretion, and glucose-stimulated insulin secretion during both intravenous and oral glucose tole rance tests. Conclusions: These data demonstrate that OSA is a key determinant of insuli n sensitivity in people with obesity and underscore the importance of taking OSA status into account whe n evaluating metabolic function in people with obesity. These findings may also have important clinical implica tions because disease progression and the risk of diabetes-related complications vary by T2D subtype (i.e. sev ere insulin resistance vs insulin deficiency). People with OSA may benefit most from the targeted treatment of periphe ral insulin resistance and early screening for complications associated with peripheral insulin resistance.
- Subjects
TYPE 2 diabetes; SLEEP apnea syndromes; GLUCOSE metabolism; POSITRON emission tomography; INSULIN resistance; ADIPOSE tissues
- Publication
European Journal of Endocrinology, 2022, Vol 186, Issue 4, p457
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-21-1025